great river Euphrates # 66_REV_09_14 # Saying to the sixth angel which had the trumpet, Loose the four angels which are bound in the great river Euphrates. great river Euphrates # 66_REV_16_12 # And the sixth angel poured out his vial upon the great river Euphrates; and the water thereof was dried up, that the way of the kings of the east might be prepared.